Biologic Abatement and Capturing Kids’ Outcomes and Flare Frequency in Juvenile Spondyloarthritis

Study Acronym / Nickname: BACK-OFF JSpA

PI(s): Pamela Weiss, MD, AB

Purpose: This trial will compare how patients with inactive spondyloarthritis on tumor necrosis factor inhibitor (TNFi) treatment respond to three treatment options that doctors currently use:

• Continue standard TNFi medication,
• Space out the time between usual TNFi medication doses, or
• Stop the TNFi medication. If we can safely prolong the time between doses or completely take away TNFi therapy in this population, we may remove unnecessary medication exposure, improve patient quality of life, and lower medication costs.

Study Design: Randomized controlled trial

PaTH Partners:

• University of Pittsburgh

Sponsor: PCORI®

The BACK-OFF JSpA study is a PCORnet® Study conducted using PCORnet®, the National Patient Centered Clinical Research Network, an initiative funded by the Patient-Centered Outcomes Research Institute (PCORI). More information about PCORnet® can be found here.

The BACK-OFF JSpA study was funded by PCORI through PCORI Award (CER-2020C1-19212).

The statements presented on this website are solely the responsibility of the author(s) and do not necessarily represent the views of other organizations participating in, collaborating with, or funding PCORnet or of PCORI.

Coordinating Center: Children’s Hospital of Philadelphia